tag:blogger.com,1999:blog-4230162007222918868.post1598886826067563703..comments2023-09-19T05:50:03.130-04:00Comments on Renal Fellow Network: Antibiotics and encephalopathyGearoid McMahonhttp://www.blogger.com/profile/08049723797363526138noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-4230162007222918868.post-2726845381306642722012-03-14T13:59:06.609-04:002012-03-14T13:59:06.609-04:00Antibiotic neurotoxicity may occur with a higher f...Antibiotic neurotoxicity may occur with a higher frequency rate when patients present in high risk conditions such as decreased renal function, low body weight, advanced age (>70 y), history of preexisting central nervous system diseases, and concurrent use of drugs that may lower the seizures threshold.It is believed that the seizure-inducing potential of the β-lactam may be due to theit chem. similaritity to the structure of the GABA neurotransmitter and antagonism at the GABA receptor site.<br />I have seen two cases of cefepime neurotoxicity and two cases of drug-induced seizures after intermittent IP administration of cefazolin for PD-related peritonitis.Francesco Iannuzzellanoreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-55240156248614516672012-03-14T02:51:44.729-04:002012-03-14T02:51:44.729-04:00In our experience in Cape Town (South Africa) we h...In our experience in Cape Town (South Africa) we have seen that the carbapenems (especially ertapenem) causing drug-induced CNS complications which includes psychosis, seizures and even coma in both renal transplant recipients and patients with advanced CKD.Yazied Chothiahttps://www.blogger.com/profile/06183136440344669102noreply@blogger.com