tag:blogger.com,1999:blog-4230162007222918868.post5530420472752962852..comments2023-09-19T05:50:03.130-04:00Comments on Renal Fellow Network: Are all thiazides created equal?Gearoid McMahonhttp://www.blogger.com/profile/08049723797363526138noreply@blogger.comBlogger7125tag:blogger.com,1999:blog-4230162007222918868.post-52495470715865124722010-11-14T19:21:39.838-05:002010-11-14T19:21:39.838-05:00Any studies that look at changes in hemodynamic pa...Any studies that look at changes in hemodynamic parameters with thiazides versus chlorthalidone? thanksAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-31803227333132833342010-11-08T13:30:32.879-05:002010-11-08T13:30:32.879-05:00You are right-- ALLHAT was designed to evaluate th...You are right-- ALLHAT was designed to evaluate the effects of several antihypertensive medications. A more correct sentence would have been "chlorthalidone has been the thiazide used in many trials, most notably ALLHAT, where blood pressure control with thiazides showed similar morbidity and mortality benefits as with other antihypertensives". The main point was to emphasize that chlorthalidone was the thiazide used in that trial.lisajcohenhttps://www.blogger.com/profile/04239296105462974113noreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-38918160974069419682010-11-08T09:00:08.922-05:002010-11-08T09:00:08.922-05:00I think you are misrepresenting the aim and result...I think you are misrepresenting the aim and results of the ALLHAT trial. You write:<br /><br /><i>ALLHAT, showing morbidity and mortality benefit from blood pressure control</i><br /><br />The primary endpoint showed no difference in the effectiveness of chlorthalidone, lisinopril and amlodipine. From <a href="http://jama.ama-assn.org/cgi/content/abstract/288/23/2981" rel="nofollow">the abstract</a>:<br /><br /><i>Mean follow-up was 4.9 years. The primary outcome occurred in 2956 participants, with no difference between treatments... Likewise, all-cause mortality did not differ between groups</i>Kidney_Boyhttps://www.blogger.com/profile/03706593315253399631noreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-16199175402129522722010-09-15T04:13:30.481-04:002010-09-15T04:13:30.481-04:00Check this out!
http://www.ncbi.nlm.nih.gov/pubme...Check this out!<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/20111008<br /><br />Meta-analysis of dose-response characteristics of hydrochlorothiazide and chlorthalidone: effects on systolic blood pressure and potassium.<br /><br />They agree with you Lisa :-). Keep up the good work.MMRnoreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-6406059026235689562010-09-01T00:29:02.481-04:002010-09-01T00:29:02.481-04:00I have been interested in the metabolic hazards of...I have been interested in the metabolic hazards of thiazides for some time. You might find these posts interesting:<br /><br />http://doctorrw.blogspot.com/2006/01/hyponatremia-hypokalemia-and-thiazide.html<br /><br />http://doctorrw.blogspot.com/2006/01/hyponatremia-hypokalemia-and-thiazide_23.html<br /><br />http://doctorrw.blogspot.com/2008/09/thiazide-diuretics-hypokalemia-and.html<br /><br />http://doctorrw.blogspot.com/2008/09/how-will-new-data-on-diuretics-and.htmlRobert W Donnellhttps://www.blogger.com/profile/16944231400440786271noreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-48888138323412338232010-08-31T22:13:08.766-04:002010-08-31T22:13:08.766-04:00Oops, I screwed up! Second chlorthalidone should ...Oops, I screwed up! Second chlorthalidone should be HCTZ. Will edit the post.lisajcohenhttps://www.blogger.com/profile/04239296105462974113noreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-11441785246856737992010-08-31T13:27:30.207-04:002010-08-31T13:27:30.207-04:00"After eight weeks, the chlorthalidone group ..."After eight weeks, the chlorthalidone group showed a significantly greater reduction in 24h ambulatory blood pressure compared to chlorthalidone..."<br /><br />Is the second "chlorthalidone" in that sentence supposed to be "hctz"? (or is the first one supposed to be hctz?) I'm easily confused!!Anonymousnoreply@blogger.com