tag:blogger.com,1999:blog-4230162007222918868.post7452143707273362087..comments2023-09-19T05:50:03.130-04:00Comments on Renal Fellow Network: Clinical Pearl - Bleeding and Liver DiseaseGearoid McMahonhttp://www.blogger.com/profile/08049723797363526138noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-4230162007222918868.post-68275207262170845882017-01-16T16:46:33.055-05:002017-01-16T16:46:33.055-05:00Controversial. "Cirrhosis has been variably a...Controversial. "Cirrhosis has been variably associated with laboratory changes favoring hyperfibrinolysis, such as increased levels of t-PA and reduced levels of plasmin inhibitor and TAFI, but also with changes favoring hypofibrinolysis, such as reduced levels of plasminogen and increased levels of PAI." In vitro assays of fibrinolytic components are likely to be misleading - as are standard coag tests are in defining the bleeding tendency of liver disease. All unsatisfactory; more work needed. <br />Ref: Tripodi and Mannucci 2011, The coagulopathy of liver disease (nice review) NEJM 365:147-56Neil Turnerhttps://www.blogger.com/profile/07623179718004986592noreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-20816695751037546942016-12-30T07:03:06.005-05:002016-12-30T07:03:06.005-05:00some references would be nice. Thank yousome references would be nice. Thank youAnonymousnoreply@blogger.com