tag:blogger.com,1999:blog-4230162007222918868.post7874880753828701833..comments2023-09-19T05:50:03.130-04:00Comments on Renal Fellow Network: The power of TGearoid McMahonhttp://www.blogger.com/profile/08049723797363526138noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-4230162007222918868.post-79082662348708260252011-02-06T08:25:02.819-05:002011-02-06T08:25:02.819-05:00Thank you for your comment. It is a good question...Thank you for your comment. It is a good question about what to measure: in this case, they measured both total testosterone, sex-hormone-binding-globulin (SHBG), and albumin and calculated the "free" and the "bioavailable" testosterone from those three parameters. I think bioavailable is the free+albumin bound hormone fraction, which is presumed to be easier to dissociate than the one bound to SHBG. The article reported the association with total testosterone and mortality, and in the analysis controlled for SHBG and albumin. It is not clear to me which is the best parameter to measure, though, and that will hopefully be refined as people look at this association more. MartaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-64784929956693838572011-02-05T12:15:40.689-05:002011-02-05T12:15:40.689-05:00Interesting, as ever - but in this case it would b...Interesting, as ever - but in this case it would be simplicity itself to do an RCT of replacement versus placebo. Also, should we look at total testosterone, or free testosterone, in this population ?David Goldsmithhttps://www.blogger.com/profile/01556939144192952081noreply@blogger.com