tag:blogger.com,1999:blog-4230162007222918868.post8576160671175409778..comments2023-09-19T05:50:03.130-04:00Comments on Renal Fellow Network: FDA, Statin and Transplantation - A conundrumGearoid McMahonhttp://www.blogger.com/profile/08049723797363526138noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-4230162007222918868.post-38782378198123608402015-09-25T03:14:08.273-04:002015-09-25T03:14:08.273-04:00I am a liver Transplant recipient,2002.The last tw...I am a liver Transplant recipient,2002.The last two years,my muscle spasms and cramps in all extremities have increased to high levels of intolerance! I do not take any statins I am aware of,but I am on prograf (Tachrolimus) for life,and wondering if there is a connection? I suffer from High blood pressure,52 years old,and symptoms are severe! Is there a relation somewhere that I can bring to a doctors attention for treatment?Joseph Andersonnoreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-14511563833367115502011-10-13T20:28:21.488-04:002011-10-13T20:28:21.488-04:00one thing to consider is that not only is cyclospo...one thing to consider is that not only is cyclosporine a CYP inhibitor (more than FK) but it also inhibits OATP which uptakes statins into the liver. This is why the risk of myopathy is much greater with cyclosporine. FK has no effect on OATP.prodruggisthttps://www.blogger.com/profile/13701626783028536150noreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-17348266988361060812011-07-20T19:23:27.326-04:002011-07-20T19:23:27.326-04:00Thanks for you comments. That is a great point and...Thanks for you comments. That is a great point and it seems the greatest risk on the PLANET trials was with the highest dose of rosuvastatin. I have not seen the data myself but it could definitely complicate even further the picture. Let's keep an eye for published data of these trials... They will deserve another blog... Meanwhile, the only thing we can do is to use <50% of the recommended maximal dose of any statin. It will likely keep us out of trouble...Leonardo V Riella, MD, PhDhttps://www.blogger.com/profile/15792108173522906438noreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-62378095568839191552011-07-20T13:27:45.382-04:002011-07-20T13:27:45.382-04:00Considering rosuvastatin's potentially deleter...Considering rosuvastatin's potentially deleterious effects on proteinuria and GFR (as shown in the recent PLANET trials), one might similarly question its safety in the transplant setting. Danged if you do, danged if you don't. Perhaps ezetimibe can play a greater role.Anonymousnoreply@blogger.com