tag:blogger.com,1999:blog-4230162007222918868.post8682405177508959246..comments2023-09-19T05:50:03.130-04:00Comments on Renal Fellow Network: Cool New Cell Paper Demonstrates Molecular Basis for Thyroxic Hypokalemic Periodic ParalysisGearoid McMahonhttp://www.blogger.com/profile/08049723797363526138noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-4230162007222918868.post-62270115692579355692011-10-08T00:16:38.662-04:002011-10-08T00:16:38.662-04:00excuse me but I think I need illumination here. Is...excuse me but I think I need illumination here. Is this kir 2.6 one of many gene that regulate the function of Na/K-ATPase or is it a whole different channel?Tywin Shavepatehttps://www.blogger.com/profile/10594042113136312317noreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-27535792398121154722010-03-07T08:01:32.136-05:002010-03-07T08:01:32.136-05:00Here is a link to more information about the genet...Here is a link to more information about the genetics of Hypokalemic Periodic Paralysis that was prepared by our genetic counselor and which has links to some useful resources for those dealing with this condition: http://www.accessdna.com/condition/Hypokalemic_Periodic_Paralysis/199. There is also a phone number listed if you need to speak to a genetic counselor by phone. I hope it helps. Thanks, AccessDNAshashankhttps://www.blogger.com/profile/00619194751575071216noreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-65944497298817895472010-01-21T10:20:47.869-05:002010-01-21T10:20:47.869-05:00Logical hypothesis involving Kir2.6 regulation by ...Logical hypothesis involving Kir2.6 regulation by insulin and/or catechols. The paper focused on thyroid hormone I imagine because thyrotoxicosis is such an important part of the disease and also because they found a thyroid response element in the promoter of the Kir2.6 gene. <br /><br />It's also possible insulin/catechols do NOT have any direct Kir2.6 regulatory effects--but instead help precipitate flaccid paralysis due to their ability to independently lower K via intracellular shift. Perhaps the combination of Kir2.6 mutation and eating a giant Chipotle burrito (mmmm!) could do this. <br /><br />Thanks for your comments.nathanhellmanhttps://www.blogger.com/profile/05106304347173760122noreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-12006156538931469072010-01-20T23:07:04.970-05:002010-01-20T23:07:04.970-05:00Very interesting.
I saw a case of TPP as an inter...Very interesting.<br /><br />I saw a case of TPP as an intern. 19 yo asian male college student recently diagnosed with Grave's who was brought in flaccid by his roommates. He had played basketball then had a massive Chipotle burrito just hours prior. K was 1.8.<br /><br />I wonder if insulin and catechols have potentiating effects on this Kir2.6 channel as they do on the Na/K ATPase?The Chiefshttps://www.blogger.com/profile/11973661374663099358noreply@blogger.com