tag:blogger.com,1999:blog-4230162007222918868.post8789653066037866531..comments2023-09-19T05:50:03.130-04:00Comments on Renal Fellow Network: Middle MoleculesGearoid McMahonhttp://www.blogger.com/profile/08049723797363526138noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-4230162007222918868.post-75875551043036738102008-11-05T14:07:00.000-05:002008-11-05T14:07:00.000-05:00It is not useful to dialyze a myeloma kidney witho...It is not useful to dialyze a myeloma kidney without chemotherapy treatment; but if you stop the paraprotein production with chemotherapy (whatever protocol it is) you can dialyze with a large pore dialyzer in order to avoid further kidney damage.<BR/>There some trial working in that area. We will see the resultsUnknownhttps://www.blogger.com/profile/05196014908434901157noreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-91536852649895198742008-11-04T21:05:00.000-05:002008-11-04T21:05:00.000-05:00Thanks for the comment! That makes sense regardin...Thanks for the comment! <BR/><BR/>That makes sense regarding having to use a super-flux membrane for dialyzing paraproteinemias. <BR/><BR/>My understanding is that the reason this is not that effective in treating myeloma kidney is because the antibody is rapidly re-synthesized and thus one would need nearly constant dialysis in order to prevent renal damage from occurring.nathanhellmanhttps://www.blogger.com/profile/05106304347173760122noreply@blogger.comtag:blogger.com,1999:blog-4230162007222918868.post-67871431189030140202008-11-04T17:46:00.000-05:002008-11-04T17:46:00.000-05:00Molecular weight of light chains is 25 kDa, but th...Molecular weight of light chains is 25 kDa, but this is mainly referred to kappa light chains, that are monomeric; lambda light chains are usually dimeric, thus their MW is 50 kDa, not dialyzable with most membranes (super-flux membranes cut-off is around 50 kDa), except with high cut-off membranes.<BR/>You need a large pore membrane to dialyze paraproteinemias.Unknownhttps://www.blogger.com/profile/05196014908434901157noreply@blogger.com