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Diarrhea & common immunosuppressants
Did you know that diarrhea increases the absorption of Prograf (tacrolimus, FK506)? Drug levels must be monitored closely in this setting to avoid tacrolimus-induced allograft toxicity. Tacrolimus is even considered a cause of diarrhea by some, though its usual counterpart in immunosuppresion, mycophenolate mofetil (MMF, Cell Cept) is more frequently associated with such GI side effects. A newer formulation of MMF, termed Myfortic, allegedly causes less GI side effects than Cell Cept, and can be used in patients in whom Cell Cept is simply not tolerated.
Did you know that diarrhea increases the absorption of Prograf (tacrolimus, FK506)? Drug levels must be monitored closely in this setting to avoid tacrolimus-induced allograft toxicity. Tacrolimus is even considered a cause of diarrhea by some, though its usual counterpart in immunosuppresion, mycophenolate mofetil (MMF, Cell Cept) is more frequently associated with such GI side effects. A newer formulation of MMF, termed Myfortic, allegedly causes less GI side effects than Cell Cept, and can be used in patients in whom Cell Cept is simply not tolerated.
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