Whenever you recommend that "cryoglobulins" be drawn on a patient, it is important to realize that the specimen must be collected in a very specific way. It cannot be simply "added on" to a specimen already drawn.Cryoglobulins are named as such because they are antibodies which precipitate in the cold. In order to test for circulating cryos, a blood specimen must be drawn and immediately placed at 37 degrees. Once the blood has clotted (the test cannot be performed for patients on heparin), the sample is then centrifuged at 37 degrees, and the serum is placed at 4 degrees. Every day, the sample is checked for for turbidity; once cloudy the sample is centrifuged to give a quantitative value to the "cryocrit." Some cryoglobulins take up to 5 days to precipitate.
The "poor man's cryoglobulin" test--and faster in terms of turnaround time--is a rheumatoid factor with complement levels (C3 and C4 are both typically low in cryoglobulinemia).
No comments:
Post a Comment
Renal Fellow Network encourages comments and discussion regarding the posts. Do not post any comments that are commercial or advertising in nature. Posts will be deleted if commercial or advertising comments are made. Internet users commenting on the Renal Fellow Network must post information which is true and correct to their knowledge. Sources to health/medical claims must be provided when relevant. Moderators reserve the right to erase, without notification, any comment they would judge inappropriate.