The acronym NODAT stands for "new onset diabetes after transplant". Diabetes is one of the many complications which occur in the post-renal transplant setting. The reasons for this are manifold. Transplant recipients who require long-term steroids will obviously have an increased susceptibility to diabetes and metabolic syndrome. In addition, cyclosporine inhibitors--tacrolimus moreso than cyclosporine--appear to have some direct beta-cell toxicity, as well as predisposing to hypertension and hyperlipidemia which often go hand-in-hand with the diabetic phenotype. Finally, improved renal function leads to increased insulin clearance by the kidney, and previously diabetic individuals who were previously insulin-independent may require exogenous supplementation in order to meet their insulin needs.
Monday, August 11, 2008
NODAT
The acronym NODAT stands for "new onset diabetes after transplant". Diabetes is one of the many complications which occur in the post-renal transplant setting. The reasons for this are manifold. Transplant recipients who require long-term steroids will obviously have an increased susceptibility to diabetes and metabolic syndrome. In addition, cyclosporine inhibitors--tacrolimus moreso than cyclosporine--appear to have some direct beta-cell toxicity, as well as predisposing to hypertension and hyperlipidemia which often go hand-in-hand with the diabetic phenotype. Finally, improved renal function leads to increased insulin clearance by the kidney, and previously diabetic individuals who were previously insulin-independent may require exogenous supplementation in order to meet their insulin needs.
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