Wednesday, February 25, 2009

Churg-Strauss Syndrome

Churg-Strauss Syndrome lies within the spectrum of Wegener's Granulomatosis, microscopic polyangiitis, and ANCA-associated vasculitis: all diseases which result from inflammation of small-to-medium-sized vessels. The "classic triad" of Churg-Strauss syndrome is asthma, eosinophilia, and vasculitis, and although "renal involvement" is not amongst these, it does occur in a subset of Churg-Strauss patients.

In this 2006 AJKD article looking at 116 Churg-Strauss patients, about 25% had some type of renal involvement. Of those who had rapidly progressive glomerulonephritis and crescents on biopsy, all were ANCA-positive. Renal involvement in Churg-Strauss should therefore generally be managed as an ANCA-associated vasculitis, e.g. steroids, Cytoxan, with a possible role for for plasma exchange or Rituxan.
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1 comment:

  1. Ken AbbottFebruary 8, 2014 at 9:02 PM

    Great CSS info. Here's my first hand account of my fight with Churg Strauss Syndrome. Hopefully it will help others. Churg Strauss - My Story http://www.churg-strauss-syndrome.com

    -Ken

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