Tuesday, October 14, 2008

Treating Lupus Nephritis During Pregnancy

It is somewhat controversial whether or not pregnant women with lupus experience flares more frequently than their non-pregnant counterparts.  Regardless, however, the issue of a lupus flare in a pregnant patient is not uncommon, especially considering that the disease tends to affect young females.

In general, the mainstays of treatment for lupus flares during pregnancy are AZATHIOPRINE and STEROIDS; both have had a pretty good track record for safety in pregnancy.  Low-dose cyclosporin A may also be a consideration, and for patients in whom there is evidence of anti-phospholipid antibody syndrome, clot prophylaxis should be initiated with aspirin or low-molecular weight heparin.  

Drugs specifically to be avoided in lupus pregnancies are CYCLOPHOSPHAMIDE (which unequivocally causes birth defects, especially during the 1st trimester) and MYCOPHENOLATE MOFETIL (which recently has been shown to result in ear and other facial malformations such as cleft lip and cleft palate).  

1 comment:

natasha said...

Disease.com is currently in the progress of choosing blogs to receive recognition from Disease.com as Top Blogs. This award is not meant to be anything other than a recongnition that your blog gives information about tactics that directly or in directly raise health awareness and prevent the transmition of Disease. Simply place the award banner code on your site and your blog will be listed as a Top Blog on Disease.com. Disease.com is a Private Global Health Watch Group. Whose goal is to promote healthy living though the spread of information globally. Thank you for your dedication to your blog. Please reply me back with the subject line as your URL to avoid spam and to make sure that you only get the award banner.

If your Believe in our Goal of Global Health Text link to use for your readers.

Text Link: Disease Url: http://www.Disease.com