Saturday, June 13, 2009


As you may recall, macroglossia (an enlarged tongue) is one of the many manifestations of amyloidosis, the systemic disorder in which a particular protein is deposited as Congo-red positive aggregations. You may also recall that amyloidosis can be divided into subtypes based on the amyloidogenic protein: for instance, there is AL amyloidosis (caused by deposition of Ig light chain, occuring in various paraproteinemias), AA amyloidosis (caused by deposition of serum amyloid A protein, elevated in inflammatory states), beta-2-microglobulin amyloidosis (caused by deposition of beta-2-microglobulin, usually in the joints, as a consequence of reduced middle molecule clearance in dialysis patients), etc. I learned today, however, that macroglossia is a unique complication of AL amyloidosis.

I have learned this, and many other renal factoids, at this year's Massachusetts General Hospital 2009 Nephrology Update. It's free for me (since I'm a fellow at MGH) and about 5 minutes from my house, and a way to force myself into doing at least a little bit of review for the Nephrology Boards. In any case, I have a whole list of new blog topics for the coming weeks...


Anonymous said...

Macroglosia can be a feature in hypothyroidism also.

pupil said...

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